When it comes to our immune system, the amount of food we eat has the same value as its quality. The reason being that the larger the amount of food you eat in one meal, the bigger the pressure on your immune system.

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Researchers examined subjects’ post-meal blood levels of C-reactive protein (CRP), an inflammatory molecule, and found that people who ate meals containing large amounts of calories had higher increases in CRP.

This means that eating smaller and more frequent meals may be associated with a more moderate immune system reaction than with larger meals, even if there are fewer throughout the day.
Scientists are still unclear what triggers this reaction, but one of the more reliable theories is based on the fact that a substantial part of the immune system is centered in the intestines, since that is one of the main entry points for germs and other threats into the body. Every time we swallow something, the immune system activates its “patrol” to make sure nothing is trying to infiltrate our major organs.

During the digestive process, the food breaks down into smaller molecules to allow their absorption in the small intestine. Ideally large and complex proteins should break down and be digested fully, to the level of their basic particle – amino acids. Proteins have a natural basic ability to trigger the immune system and cause an overreaction (sensitivity or allergy), but amino acids are not large or complex enough to trigger such a reaction. Agents that trigger immune reactions are also often proteins, known as antigens. To keep them from crossing the intestinal wall (the safety barrier between the bowels and the rest of the body), the digestive system needs to be strong.

Much research has been conducted on these antigens. It has been found that about 2% of the antigens found in foods cross the intestinal lining and activate the immune system. Once these antigens infiltrate the body, the chances of an immune system reaction increase. This process is one of the ways certain people develop food allergies.

It has been suggested that limiting meal size enables the digestive system to function more efficiently, to break down antigens more thoroughly, and to not overload the intestinal barrier, thus rendering it able to efficiently protect the body from antigens and microbes. Therefore, eating smaller amounts of foods at a time may be a powerful tonic for the immune system.

It is becoming clearer in another way as well that to live a longer and healthier life,  reducing the amount of food we eat – more accurately, limiting the amount of calories – may be fundamentally beneficial, beyond prevention of disease and immune overstimulation. It has been repeatedly found in animal studies that limiting caloric intake to only that needed for basic bodily functions has a profound beneficial impact on the process of aging and the lifespan. In multiple research studies with laboratory animals, it was observed that if food/caloric intake was decreased by approximately a third, the lifespan increased by 30%-40%. In human terms, if we take our current lifespan in the western world, which is about 75-80 years despite excessive intake, we may be able to reach an average lifespan of 100 years by “right-sizing” our food intake.

However, when people are asked to consume less, a problem arises: the psychology of deprivation. It would take blind obedience to have people maintain a consistently low-calorie diet. The feeling of deprivation can stir various negative feelings. If you cheat, you feel bad later; or if you succeed in maintaining a strict restrictive diet for a certain period, you may overcompensate eventually, eating more than you ever ate before.

So what can you do?

  • Eat often and soundly, but with little-to-no excess. Going low-fat and low-sugar is the easiest path. Adopting such eating habits can create a sense of fullness and won’t overload the immune system.

A sound method is to eat a light snack whenever you feel hungry, which should be about every 2-3 hours. When this happens, you can nibble on a low-fat snack, like a handful of raisins or peanuts. Main meals should be balanced combinations of multiple food groups, but each portion also just a handful.

By eating small amounts of food frequently, immune system activation could be mellowed. In fact, you could even say that every large meal that is “right-sized” translates to prevention of accelerated aging, and the cumulative effects may slow the hands of time. A reasonable diet that supplies adequate nutrition with reduced volume may just be the fountain of youth.

Learn how to create balanced meals for weight loss with the Trim Down Club.

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  1. Hi, atheen. Some research studies do continue to find benefits of “moderate caloric restriction” in humans as well as mice in terms of metabolic disorders associated with overweight. However, similar benefits can be provided by reducing the caloric density of foods (a slightly different concept) and providing just the right amount of calories. That is a more stable solution in humans, as caloric restriction cannot be maintained indefinitely, usually resulting in rebound weight gain and metabolic problems related just to that.

  2. Along with more water, this 2-3 hour grazing philosophy, with decreasing portion size, & concentrating on fruits & veggies does seem to have positive results. The hurdle of the initial commitment, and then the ongoing discipline to stick to it, sure takes us closer continually to our desired weight.

  3. I think more recent studies have not found the age enhancing effects of a lower calorie diet among research animals, most particularly not among primates–as the article regarding the recent study noted, it takes a long time to determine a primate’s lifetime, so instant results weren’t possible in the earlier studies–and rats and mice are not close to humans in their responses to things. Monderation in everything is always a good motto when addressing the findings of new studies.

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